Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Sectoral Asset Management Inc

Citizenship or Place of Organization : Canada

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Jérôme G. Pfund

Citizenship or Place of Organization : Swiss

IN

Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only).

Michael L. Sjöström

Citizenship or Place of Organization : Swiss

Address of Issuer's Principal Executive Offices:
2 W. Liberty Blvd #100

Malvern, Pennsylvania, 19355

USA

Name of Person(s) Filing:

Sectoral Asset Management Inc.

Jérôme G. Pfund

Michael L. Sjöström

Address of Principal Business Office or, if none, Residence:

The principal business address of each of the Reporting Persons is:
1610-1010 Sherbrooke St. West, Montreal QC, H3A 2R7 Canada

Citizenship:

Sectoral Asset Management Inc. is a Canadian corporation
Jérôme G. Pfund is a Swiss citizen
Michael L. Sjöström is a Swiss citizen

Group, in accordance with § 240.13d-1(b)(1)(ii)(K).  If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution: ___________________

Item 4.        Ownership.

Sectoral Asset Management Inc, in its capacity as an investment adviser, has the sole right to dispose of or vote the number of shares of common stock of the Issuer set forth in this filing. Jérôme G. Pfund and Michael L. Sjöström, together, hold majority of shares of Sectoral Asset Management Inc. Sectoral Asset Management, Inc. and Messrs. Pfund and Sjöström disclaim beneficial ownership of the Issuer’s common stock held by Sectoral Asset Management Inc.

Amount beneficially owned:

Sectoral Asset Management Inc.: 1,666,666 shares

Jérôme G. Pfund: 1,666,666 shares

Michael L. Sjöström: 1,666,666 shares

Percent of class:

Sectoral Asset Management Inc.: 5.8%

Jérôme G. Pfund: 5.8%

Michael L. Sjöström: 5.8%

Sole power to vote or to direct the vote:

Sectoral Asset Management Inc.: 689,175 shares

Jérôme G. Pfund: 689,175 shares

Michael L. Sjöström: 689,175 shares

Sole power to dispose or to direct the disposition of:

Sectoral Asset Management Inc.: 1,666,666 shares

Jérôme G. Pfund: 1,666,666 shares

Michael L. Sjöström: 1,666,666 shares

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ¨

Ownership of More than Five Percent on Behalf of Another Person.

Various persons, as investment advisory clients of Sectoral Asset Management, Inc., have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the common stock of the Issuer. To the knowledge of Sectoral Asset Management, Inc., no one such person’s interest in the common stock of the Issuer is more than five percent of the total outstanding common stock of the Issuer.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not applicable.

Identification and Classification of Members of the Group.

Not applicable.

By signing below the undersigned each certifies that, to the best knowledge and belief of the undersigned, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.