United States securities and exchange commission logo December 7, 2020 Mel Sorensen Chief Executive Officer Galera Therapeutics, Inc. 2 W Liberty Blvd #100 Malvern, PA 19355 Re: Galera Therapeutics, Inc. Registration Statement on Form S-3 Filed December 1, 2020 File No. 333-251061 Dear Mr. Sorensen: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Margaret Schwartz at 202-551-7153 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Nathan Ajiashvili, Esq.